Tissue dielectric constant (TDC) measurements as a means of characterizing localized tissue water in arms of women with and without breast cancer treatment related lymphedema.
Identifieur interne : 002392 ( Main/Exploration ); précédent : 002391; suivant : 002393Tissue dielectric constant (TDC) measurements as a means of characterizing localized tissue water in arms of women with and without breast cancer treatment related lymphedema.
Auteurs : H N Mayrovitz ; D N Weingrad ; S. DaveySource :
- Lymphology [ 0024-7766 ] ; 2014.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Composition corporelle, Conductivité électrique, Eau corporelle (métabolisme), Femelle, Humains, Jeune adulte, Lymphoedème (diagnostic), Lymphoedème (métabolisme), Lymphoedème (étiologie), Mastectomie (effets indésirables), Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du sein (), Valeur prédictive des tests, Études cas-témoins.
- MESH :
- diagnostic : Lymphoedème.
- effets indésirables : Mastectomie.
- métabolisme : Eau corporelle, Lymphoedème.
- étiologie : Lymphoedème.
- Adolescent, Adulte, Adulte d'âge moyen, Composition corporelle, Conductivité électrique, Femelle, Humains, Jeune adulte, Sujet âgé, Sujet âgé de 80 ans ou plus, Tumeurs du sein, Valeur prédictive des tests, Études cas-témoins.
English descriptors
- KwdEn :
- Adolescent, Adult, Aged, Aged, 80 and over, Body Composition, Body Water (metabolism), Breast Neoplasms (surgery), Case-Control Studies, Electric Conductivity, Female, Humans, Lymphedema (diagnosis), Lymphedema (etiology), Lymphedema (metabolism), Mastectomy (adverse effects), Middle Aged, Predictive Value of Tests, Young Adult.
- MESH :
- adverse effects : Mastectomy.
- diagnosis : Lymphedema.
- etiology : Lymphedema.
- metabolism : Body Water, Lymphedema.
- surgery : Breast Neoplasms.
- Adolescent, Adult, Aged, Aged, 80 and over, Body Composition, Case-Control Studies, Electric Conductivity, Female, Humans, Middle Aged, Predictive Value of Tests, Young Adult.
Abstract
Quantitative measurements to detect lymphedema early in persons at-risk for breast cancer (BC) treatment-related lymphedema (BCRL) can aid clinical evaluations. Since BCRL may be initially manifest in skin and subcutis, the earliest changes might best be detected via local tissue water (LTW) measurements that are specifically sensitive to such changes. Tissue dielectric constant (TDC) measurements, which are sensitive to skin-to-fat tissue water, may be useful for this purpose. TDC differences between lymphedematous and non-lymphedematous tissue has not been fully characterized. Thus we measured TDC values (2.5 mm depth) in forearms of three groups of women (N = 80/group): 1) healthy with no BC (NOBC), 2) with BC but prior to surgery, and 3) with unilateral lymphedema (LE). TDC values for all arms except LE affected arms were not significantly different ranging between 24.8 ± 3.3 to 26.8 ± 4.9 and were significantly less (p < 0.001) as compared to 42.9 ± 8.2 for LE affected arms. Arm TDC ratios, dominant/non-dominant for NOBC, were 1.001 ± 0.050 and at-risk/ contralateral for BC were 0.998 ± 0.082 with both significantly less (p < 0.001) than LE group affected/control arm ratios (1.663 ± 0.321). These results show that BC per se does not significantly change arm LTW and that the presence of BCRL does not significantly change LTW of non-affected arms. Further, based on 3 standard deviations of measured arm ratios, our data demonstrates that an at-risk arm/contralateral arm TDC ratio of 1.2 and above could be a possible threshold to detect pre-clinical lymphedema. Further prospective measurement trial are needed to confirm this value.
PubMed: 25420307
Affiliations:
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Davey</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:25420307</idno><idno type="pmid">25420307</idno><idno type="wicri:Area/PubMed/Corpus">001190</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001190</idno><idno type="wicri:Area/PubMed/Curation">001190</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001190</idno><idno type="wicri:Area/PubMed/Checkpoint">001190</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001190</idno><idno type="wicri:Area/Ncbi/Merge">006D53</idno><idno type="wicri:Area/Ncbi/Curation">006D53</idno><idno type="wicri:Area/Ncbi/Checkpoint">006D53</idno><idno type="wicri:doubleKey">0024-7766:2014:Mayrovitz H:tissue:dielectric:constant</idno><idno type="wicri:Area/Main/Merge">002395</idno><idno type="wicri:Area/Main/Curation">002392</idno><idno type="wicri:Area/Main/Exploration">002392</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Tissue dielectric constant (TDC) measurements as a means of characterizing localized tissue water in arms of women with and without breast cancer treatment related lymphedema.</title><author><name sortKey="Mayrovitz, H N" sort="Mayrovitz, H N" uniqKey="Mayrovitz H" first="H N" last="Mayrovitz">H N Mayrovitz</name></author><author><name sortKey="Weingrad, D N" sort="Weingrad, D N" uniqKey="Weingrad D" first="D N" last="Weingrad">D N Weingrad</name></author><author><name sortKey="Davey, S" sort="Davey, S" uniqKey="Davey S" first="S" last="Davey">S. Davey</name></author></analytic><series><title level="j">Lymphology</title><idno type="ISSN">0024-7766</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Body Composition</term><term>Body Water (metabolism)</term><term>Breast Neoplasms (surgery)</term><term>Case-Control Studies</term><term>Electric Conductivity</term><term>Female</term><term>Humans</term><term>Lymphedema (diagnosis)</term><term>Lymphedema (etiology)</term><term>Lymphedema (metabolism)</term><term>Mastectomy (adverse effects)</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Young Adult</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Composition corporelle</term><term>Conductivité électrique</term><term>Eau corporelle (métabolisme)</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Lymphoedème (diagnostic)</term><term>Lymphoedème (métabolisme)</term><term>Lymphoedème (étiologie)</term><term>Mastectomie (effets indésirables)</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs du sein ()</term><term>Valeur prédictive des tests</term><term>Études cas-témoins</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Mastectomy</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="effets indésirables" xml:lang="fr"><term>Mastectomie</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Body Water</term><term>Lymphedema</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Eau corporelle</term><term>Lymphoedème</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Breast Neoplasms</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Lymphoedème</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Body Composition</term><term>Case-Control Studies</term><term>Electric Conductivity</term><term>Female</term><term>Humans</term><term>Middle Aged</term><term>Predictive Value of Tests</term><term>Young Adult</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term><term>Adulte</term><term>Adulte d'âge moyen</term><term>Composition corporelle</term><term>Conductivité électrique</term><term>Femelle</term><term>Humains</term><term>Jeune adulte</term><term>Sujet âgé</term><term>Sujet âgé de 80 ans ou plus</term><term>Tumeurs du sein</term><term>Valeur prédictive des tests</term><term>Études cas-témoins</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Quantitative measurements to detect lymphedema early in persons at-risk for breast cancer (BC) treatment-related lymphedema (BCRL) can aid clinical evaluations. Since BCRL may be initially manifest in skin and subcutis, the earliest changes might best be detected via local tissue water (LTW) measurements that are specifically sensitive to such changes. Tissue dielectric constant (TDC) measurements, which are sensitive to skin-to-fat tissue water, may be useful for this purpose. TDC differences between lymphedematous and non-lymphedematous tissue has not been fully characterized. Thus we measured TDC values (2.5 mm depth) in forearms of three groups of women (N = 80/group): 1) healthy with no BC (NOBC), 2) with BC but prior to surgery, and 3) with unilateral lymphedema (LE). TDC values for all arms except LE affected arms were not significantly different ranging between 24.8 ± 3.3 to 26.8 ± 4.9 and were significantly less (p < 0.001) as compared to 42.9 ± 8.2 for LE affected arms. Arm TDC ratios, dominant/non-dominant for NOBC, were 1.001 ± 0.050 and at-risk/ contralateral for BC were 0.998 ± 0.082 with both significantly less (p < 0.001) than LE group affected/control arm ratios (1.663 ± 0.321). These results show that BC per se does not significantly change arm LTW and that the presence of BCRL does not significantly change LTW of non-affected arms. Further, based on 3 standard deviations of measured arm ratios, our data demonstrates that an at-risk arm/contralateral arm TDC ratio of 1.2 and above could be a possible threshold to detect pre-clinical lymphedema. Further prospective measurement trial are needed to confirm this value.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Davey, S" sort="Davey, S" uniqKey="Davey S" first="S" last="Davey">S. Davey</name><name sortKey="Mayrovitz, H N" sort="Mayrovitz, H N" uniqKey="Mayrovitz H" first="H N" last="Mayrovitz">H N Mayrovitz</name><name sortKey="Weingrad, D N" sort="Weingrad, D N" uniqKey="Weingrad D" first="D N" last="Weingrad">D N Weingrad</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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